2. Signaling Pathways
  3. MAPK/ERK Pathway
  4. Mixed Lineage Kinase
  5. Mixed Lineage Kinase Degrader

Mixed Lineage Kinase Degrader

Mixed Lineage Kinase Degraders (2):

Cat. No. Product Name Effect Purity
  • HY-156591
    PROTAC MLKL Degrader-1
    		Degrader 99.76%
    PROTAC MLKL Degrader-1 (Compound 36) is a PROTAC degrader of MLKL, with a Dmax ＞90%. PROTAC MLKL Degrader-1 contains modified CRBN ligands, linker and Lenalidomide (HY-A0003)-linker fragments. PROTAC MLKL Degrader-1 abrogates cell death in a TSZ model of necroptosis.
  • HY-182343
    PROTAC MLKL Degrader-3
    		Degrader
    PROTAC MLKL Degrader-3 (compound C116) is a MLKL PROTAC degrader. PROTAC MLKL Degrader-3 induces proteasome- and cereblon-dependent MLKL degradation via ubiquitination. PROTAC MLKL Degrader-3 is applicable to the research of hepatocellular carcinoma.